Physical Stability of Carvedilol in Solid Dispersions with Porous Silica
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چکیده
منابع مشابه
Physical Stability of Carvedilol in Solid Dispersions with Porous Silica
Adsorption onto silica-based high surface area carriers is a long known method of improvement drug dissolution rate, which has been described in early 1970s [1]. Porous silica has many silanol groups on its surface and can be used as pharmaceutical excipient, since it is regarded nontoxic after oral application. Due to its porous structure and large specific surface area, porous silica has a gr...
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Solid dispersion particles of carvedilol (CAR) were prepared with porous silica (Sylysia 350) by the solvent evaporation method in a vacuum evaporator to ensure an effective pore-filling procedure. Two sets were prepared, each with various amounts of CAR in solid dispersions, and with the pore-filling process differing each time. Set A was prepared by a one-step filling method and set B by a mu...
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متن کاملpreparation and characterization of solid dispersions of carvedilol with pvp k30
solid dispersions in water-soluble carriers have attracted considerable interest as a means of improving the dissolution rate, and hence possibly bioavailability, of a range of hydrophobic drugs. the poor solubility of carvedilol leads to poor dissolution and hence variation in bioavailability. the purpose of the present investigation was to increase the solubility and dissolution rate of carve...
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ژورنال
عنوان ژورنال: Scientia Pharmaceutica
سال: 2010
ISSN: 2218-0532
DOI: 10.3797/scipharm.cespt.8-pms30